Protons. A step forward or perhaps only more expensive radiation therapy?

A More Expensive Aspirin?

U nstable angina is a syndrome in which the occlusion of coronary arteries by plateletdependent thrombus formation may result in myocardial infarction and death.' Angiographic2 and angioscopic3 evidence of thrombus formation is complemented by the measurement of increased concentrations of thromboxane (TX) metabolites in plasma and urine during ischemic episodes in patients with this disease.4 ...

Biomarkers in DILI: One More Step Forward

Despite being relatively rare, drug-induced liver injury (DILI) is a serious condition, both for the individual patient due to the risk of acute liver failure, and for the drug development industry and regulatory agencies due to associations with drug development attritions, black box warnings, and postmarketing withdrawals. A major limitation in DILI diagnosis and prediction is the current lac...

Pharmacogenetics in the Management of Coumarin Anticoagulant Therapy: The Way Forward or an Expensive Diversion?

W arfarin and related coumarin-based anticoagulants are the mainstay of pharmacological management for the long-term prevention of thromboembolism. It is estimated that over 1 million residents in the United Kingdom take warfarin; in excess of 20 million prescriptions for the anticoagulant are dispensed each year in the United States of America. Despite recent advances in the development of nov...

One step forward

The 2000 revision of the Declaration of Helsinki: a step forward or more confusion?

At a time when there was great attention and intense public controversy surrounding clinical (especially multinational) research, the 52nd general assembly of the World Medical Association (WMA) adopted the 5th revision of the Declaration of Helsinki (in October, 2000)-available at www.wma.net. These revisions are the most substantial adaptations since those adopted by the 29th WMA assembly in ...